||Exposure of Humans to a Volatile Organic Mixture. 2. Sensory.
Hudnell, H. K. ;
Otto, D. A. ;
House, D. E. ;
Molhave., L. ;
||Health Effects Research Lab., Research Triangle Park, NC. ;Aarhus Univ. (Denmark). Inst. for Miljoe- og Arbejdsmedicin.
Air pollution effects(Humans) ;
Psychomotor performance ;
Signs and symptoms ;
Indoor air pollution ;
Trigeminal nerve ;
Volatile organic compounds ;
Sick building syndrome
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||Time-course functions for symptoms of the sick building syndrome were derived from 66 healthy males exposed to clean air and a volatile organic compound (VOC) mixture in separate sessions. The mixture contained 22 VOCs (25 mg/cu m total concentration) commonly found air-borne in new or recently renovated buildings. Subjects rated the intensity of perceived irritation, odor, and other variables before and twice during 2.75 hr exposure periods. Eye and throat irritation, headache, and drowsiness increased or showed no evidence of adaptation during exposure, whereas odor intensity decreased by 30%. These results indicate that irritation intensity and other symptoms are not related in any simple fashion to odor intensity, suggesting that the symptoms may not be a psychosomatic response to detection of an aversive odor. Instead, subthreshold levels of VOCs may interact additively or hyperadditively and stimulate trigeminal nerve receptors.
||Pub. in Archives of Environmental Health, v47 n1 p31-38 Feb 92. See also PB90-186438. Portions of this document are not fully legible. Prepared in cooperation with Aarhus Univ. (Denmark). Inst. for Miljoe- og Arbejdsmedicin.
|NTIS Title Notes
||Reprint: Exposure of Humans to a Volatile Organic Mixture. 2. Sensory.
||68G; 68A; 57Y; 57S
||PC A03/MF A01