| Main Title |
Critical Evaluation of Methods for Detection and Assessment of Estrogenic Compounds in Mammals: Strengths and Limitations for Application to Risk Assessment. |
| Author |
Kupfer, D. L. ;
|
| CORP Author |
Worcester Foundation for Experimental Biology, Shrewsbury, MA.;Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment. |
| Publisher |
c1988 |
| Year Published |
1988 |
| Report Number |
EPA/600/J-88/294 ; OHEA-R-255 |
| Stock Number |
PB89-202295 |
| Additional Subjects |
Reproduction(Biology) ;
Toxicology ;
Sex hormones ;
Estrogens ;
Reprints ;
Xenobiotics ;
Risk assessment ;
Proestrogens ;
Therapeutic agents
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB89-202295 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
10p |
| Abstract |
Methods for assessing proestrogenic and estrogenic activity of xenobiotics (environmental pollutants and therapeutic agents) are critically evaluated. The uterotropic assay in vivo and the binding affinity to the uterine estrogen receptor in vitro are still the preferred methods by most investigators. Because metabolism could markedly alter the activity of estrogens and proestrogens, in vitro methods that do not consider such possibilities have only limited utility. An in vitro method, which attempts to satisfy that requirement by combining metabolic capability with binding to the estrogen receptor, has become available. However, this method still needs considerable refinement and the assessment of its potential and limitations. In addition, there is a need for a facile method for determining whether a compound is a frank estrogen or a partial agonist/antiestrogen. These methods are considered in respect to their application for risk assessment. (Copyright (c) 1988 Pergamon Press plc.) |
| Supplementary Notes |
Pub. in Reproductive Toxicology, v1 n2 p147-153 Jun 88. Sponsored by Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Critical Evaluation of Methods for Detection and Assessment of Estrogenic Compounds in Mammals: Strengths and Limitations for Application to Risk Assessment. |
| Category Codes |
57Y; 57E |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/21 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
924218054 |
| Origin |
NTIS |
| Type |
CAT |
