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RECORD NUMBER: 4 OF 8Main Title | Mid-Frequency Hearing Loss in Rats Following Inhalation Exposure to Trichloroethylene: Evidence from Reflex Modification Audiometry. | |||||||||||
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Author | Crofton, K. M. ; Zhao, X. ; | |||||||||||
CORP Author | Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div. ;ManTech Environmental Technology, Inc., Research Triangle Park, NC. | |||||||||||
Publisher | 1993 | |||||||||||
Year Published | 1993 | |||||||||||
Report Number | EPA/600/J-94/078; | |||||||||||
Stock Number | PB94-141504 | |||||||||||
Additional Subjects | Hearing disorders ; Toxicity ; Trichloroethylene ; Acoustic reflex ; Graphs(Charts) ; Audiometry ; Spectrum analysis ; Sensory thresholds ; Reprints ; | |||||||||||
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Collation | 13p | |||||||||||
Abstract | The present experiments were undertaken to characterize the hearing loss associated with 1,1,2-trichloroethylene (TCE) exposure. Adult male Long-Evans (LE) rats were exposed to TCE via inhalation (whole body) for 6 h/day for 5 days. The concentration-effect function (0-4000 ppm) was determined 3 weeks post-exposure. Animals were tested for auditory thresholds to 4, 8, 16, 24, 32, and 40-kHz tones using reflex modification audiometry. In a separate experiment, the time course of effects was determined by monitoring 16-kHz thresholds prior to, 1 h following each of the 5 exposure days, and 5 days, 1, 2, 4, 8, and 12 weeks post-exposure. At 14 weeks, these same animals were tested for thresholds to 0.5, 1, 2, 4, 8, 16, 24, 32, and 40-kHz tones. Results indicate elevated thresholds (hearing loss) for the 4000 ppm group at 8 and 16 kHz of approximately 18 and 30 dB, respectively. Time-course data demonstrated a rapid onset, a 20-dB loss at 16 kHz after the fifth exposure day, and a 40-dB loss by 2 weeks that persisted up to 14 weeks post-exposure. These data demonstrate an atypical and persistent, mid-frequency hearing loss in rats following inhalation exposure to TCE. (Copyright (c) 1993 Pergamon Press Ltd.) | |||||||||||
Supplementary Notes | Pub. in Neurotoxicology and Teratology, v16 n6 p413-423 1993. See also PB93-182533. Prepared in cooperation with ManTech Environmental Technology, Inc., Research Triangle Park, NC. | |||||||||||
NTIS Title Notes | Journal article. | |||||||||||
Title Annotations | Reprint: Mid-Frequency Hearing Loss in Rats Following Inhalation Exposure to Trichloroethylene: Evidence from Reflex Modification Audiometry. | |||||||||||
Category Codes | 57Y; 57S | |||||||||||
NTIS Prices | PC A03/MF A01 | |||||||||||
Primary Description | 600/10 | |||||||||||
Document Type | NT | |||||||||||
Cataloging Source | NTIS/MT | |||||||||||
Control Number | 409119733 | |||||||||||
Origin | NTIS | |||||||||||
Type | CAT |