| Main Title |
Functional Deficits Produced by 3-Methylindole-Induced Olfactory Mucosal Damage Revealed by a Simple Olfactory Learning Task. |
| Author |
Peele, D. B. ;
Allison, S. D. ;
Bolon, B. ;
Prah, J. D. ;
Jensen, K. F. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc., Research Triangle Park, NC. ;Chemical Industry Inst. of Toxicology, Research Triangle Park, NC. |
| Publisher |
c1991 |
| Year Published |
1991 |
| Report Number |
EPA/600/J-91/018; |
| Stock Number |
PB91-183483 |
| Additional Subjects |
Toxicology ;
Skatole ;
Nasal mucosa ;
Rats ;
Sensory thresholds ;
Cognition ;
Animal behavior ;
Pathology ;
Reprints ;
Olfactory learning
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB91-183483 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
14p |
| Abstract |
Methods for assessing functional consequences of olfactory mucosal damage were examined in rats exposed to 3-methylindole (3-MI). Treatment with 3-MI (400 mg/kg) induced severe degeneration of olfactory sensory epithelium followed by regeneration, fibrous adhesions and osseous remodeling of the nasal passages. At 100 mg/kg, there was mild Bowman's gland hypertrophy while the sensory epithelium remained intact. Rats treated with 3-MI demonstrated a dosage-related deficit in acquiring an olfactory learning task which was not due to altered cognitive abilities, as determined by subsequent testing in a step-through passive avoidance task. The results confirm the conclusion that alterations in functional indices resulted from 3-MI-induced anosmia and demonstrate the utility of simple learning tasks in assessing functional capacity following olfactory epithelial damage in rats. (Copyright (c) 1991 Academic Press, Inc.) |
| Supplementary Notes |
Pub. in Toxicology and Applied Pharmacology, v107 n2 p191-201 Feb 91. Prepared in cooperation with Northrop Services, Inc., Research Triangle Park, NC., and Chemical Industry Inst. of Toxicology, Research Triangle Park, NC. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Functional Deficits Produced by 3-Methylindole-Induced Olfactory Mucosal Damage Revealed by a Simple Olfactory Learning Task. |
| Category Codes |
57U; 57S |
| NTIS Prices |
PC A03/MF A01 |
| Primary Description |
600/10 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
117927397 |
| Origin |
NTIS |
| Type |
CAT |
