||Acute and Long-Term Effects of a Single Dose of the Fungicide Carbendazim (Methyl 2-Benzimidazole Carbamate) on the Male Reproductive System in the Rat.
Nakai, M. ;
Hess, R. A. ;
Moore, B. J. ;
Guttroff, R. F. ;
Strader., L. F. ;
||Health Effects Research Lab., Research Triangle Park, NC. ;Illinois Univ. at Urbana-Champaign. Dept. of Veterinary Biosciences. ;Miyazaki Univ. (Japan). Dept. of Veterinary Anatomy.;National Institutes of Health, Bethesda, MD.
Reproductive system ;
Dose-response relationships ;
Seminiferous tubules ;
Organ weight ;
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||The effects of carbendazim (methyl 2-benzimidazole carbamate) on the testis, efferent ductules, and sperm were determined in the adult rate after a single oral dose. Two experimental trials were performed: a time response between 2 hours and 32 days after exposure using 0 and 400 mg/kg, and a dose response at 2 and 70 days after exposure using 0 to 800 mg/kg doses. A dose-dependent increase in testicular weight 2 days after treatment was accompanied by increases in seminiferous tubular diameter and excessive loss of immature germ cells in a stage-dependent manner. There was also a dose-dependent increased incidence of occlusions in the efferent ductules. The occluded ductules were characterized by severe inflammation and exhibited disorganization of the epithelium. At 70 days, there were dose-dependent decreases in mean testis weight and mean seminiferous tubular diameter; however, only minimal long-term effects were seen at 50 mg/kg. Results show that carbendazim produces more severe short- and long-term effects on the male reproductive system than the fungicide benomyl.
||Pub. in Jnl. of Andrology, v13 n6 p507-518 Nov/Dec 92. Prepared in cooperation with Illinois Univ. at Urbana-Champaign. Dept. of Veterinary Biosciences. and Miyazaki Univ. (Japan). Dept. of Veterinary Anatomy. Sponsored by National Institutes of Health, Bethesda, MD.
||%AUT:R. E. /Linder
|NTIS Title Notes
||Reprint: Acute and Long-Term Effects of a Single Dose of the Fungicide Carbendazim (Methyl 2-Benzimidazole Carbamate) on the Male Reproductive System in the Rat.
||PC A03/MF A01