| Main Title |
Long-Term Neurochemical and Behavioral Effects Induced by Acute Chlorpyrifos Treatment. |
| Author |
Pope, C. N. ;
Chakraborti, T. K. ;
Chapman, M. L. ;
Farrar, J. D. ;
|
| CORP Author |
Northeast Louisiana Univ., Monroe. School of Pharmacy.;Health Effects Research Lab., Research Triangle Park, NC. |
| Publisher |
c1992 |
| Year Published |
1992 |
| Report Number |
EPA/600/J-92/256; |
| Stock Number |
PB92-206366 |
| Additional Subjects |
Dursban ;
Toxicology ;
Neurochemistry ;
Motor activity ;
Cholinesterase inhibitors ;
Corpus striatum ;
Cerebral cortex ;
Muscarinic receptors ;
Rats ;
Binding sites ;
Scopolamine ;
Reprints ;
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB92-206366 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
8p |
| Abstract |
A single, maximal tolerated dose of the organophosphate insecticide chlorpyrifos (CPF, 279 mg/kg, sc) caused extensive inhibition of striatal and cortical cholinesterase (ChE) activity in adult rats at two (94-96%), four (64-74%) and six (36-38%) weeks after treatment. These persistent changes in ChE activity were concomitant with significant reductions in striatal muscarinic receptor (3H quinuclidinyl benzilate) binding sites (50, 31 and 18% reduction in B max at 2, 4 and 6 weeks after exposure) and a slight but significant alteration in the apparent affinity constant, K(D), at 2 and 4 weeks after treatment. Neither ChE activity nor muscarinic receptor binding were different from control levels at 12 weeks after exposure. CPF treatment caused a significant reduction in motor activity for the first two days after treatment, after which basal activity levels were not different from controls. These data indicate that a single, acute exposure to CPF in adult rats can cause long-term neurobehavioral/neuropharmacological changes which may persist following the recovery of neurochemical parameters generally associated with OP exposure and/or tolerance. |
| Supplementary Notes |
Pub. in Pharmacology Biochemistry and Behavior, v42 n2 p251-256 Jun 92. Sponsored by Health Effects Research Lab., Research Triangle Park, NC. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Long-Term Neurochemical and Behavioral Effects Induced by Acute Chlorpyrifos Treatment. |
| Category Codes |
57Y; 57B; 57S; 68E |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/10 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
226924059 |
| Origin |
NTIS |
| Type |
CAT |
