| Main Title |
Genetic Toxicology of Benzoin and Caprolactam. |
| Author |
Brady, A. L. ;
Stack, H. F. ;
Waters, M. D. ;
|
| CORP Author |
Environmental Health Research and Testing, Inc., Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC. Genetic Toxicology Div. |
| Publisher |
c1989 |
| Year Published |
1989 |
| Report Number |
EPA-68-02-4456; EPA/600/J-89/384; |
| Stock Number |
PB90-216151 |
| Additional Subjects |
Toxicology ;
Mutations ;
Bioassay ;
Tables(Data) ;
Drosophila ;
Salmonella typhimurium ;
Saccharomyces ;
Reprints ;
Mutagenicity tests ;
Caprolactan ;
Benzoin ;
Transformed cell line
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB90-216151 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
15p |
| Abstract |
Based on animal carcinogenesis studies, benzoin and caprolactam have been classified as noncarcinogens. The genetic toxicity of both compounds has been thoroughly evaluated in short-term in vitro bioassays. Genetic activity profiles and corresponding data listings and summaries are presented for benzoin and caprolactam. Generally weak positive responses were obtained with benzoin only in mammalian cell mutagenesis and cell transformation assays. In the case of caprolactam, reproducible positive responses were obtained for somatic mutations in Drosophila and for mammalian cell transformation (in different cell lines) at high dose levels. Since the chemical structures of benzoin and caprolactam do not suggest the potential for genotoxicity, these responses may be associated with nonspecific toxicity. The overwhelming majority of short-term test data suggest that, in accordance with animal cancer data, benzoin and caprolactam are not genotoxic. (Copyright (c) Elsevier Science Publishers B. V. (Biomedical Division).) |
| Supplementary Notes |
Pub. in Mutation Research, v224 p391-403 Nov 89. Sponsored by Health Effects Research Lab., Research Triangle Park, NC. Genetic Toxicology Div. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Genetic Toxicology of Benzoin and Caprolactam. |
| Category Codes |
57Y; 57F |
| NTIS Prices |
PC A03/MF A01 |
| Primary Description |
600/10 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
018016102 |
| Origin |
NTIS |
| Type |
CAT |
