| Main Title |
Design and Implementation of a Collaborative Study of the Mutagenicity of Complex Mixtures in 'Salmonella typhimurium'. |
| Author |
Lewtas, J. ;
Claxton, L. D. ;
Rosenkranz, H. S. ;
Schuetzle, D. ;
Shelby, M. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. Genetic Toxicology Div. ;Pittsburgh Univ., PA. Dept. of Environmental and Occupational Health. ;Ford Motor Co., Dearborn, MI. Scientific and Research Lab. ;National Inst. of Environmental Health Sciences, Research Triangle Park, NC. ;National Inst. of Public Health, Tokyo (Japan). |
| Publisher |
c1992 |
| Year Published |
1992 |
| Report Number |
EPA/600/J-92/055; |
| Stock Number |
PB92-150697 |
| Additional Subjects |
Salmonella typhimurium ;
Toxic substances ;
Mutagens ;
Mixtures ;
Air pollutants ;
Mutagenicity tests ;
Bioassay ;
Aromatic polycyclic hydrocarbons ;
Coal tar ;
Interlaboratory comparisons ;
Reprints ;
Standard Reference Materials
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB92-150697 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
8p |
| Abstract |
An international collaborative study of the mutagenicity of complex environmental mixtures in the Ames Salmonella typhimurium mutation assay was performed. The objectives of the study were: (1) to estimate the inter and intra-laboratory variability associated with the extraction of mixtures for bioassay, (2) to estimate the inter and intra-laboratory variability associated with the Salmonella typhimurium bioassay when applied to complex mixtures, (3) to determine if mutagenicity values can be determined from this collaborative study for issuance with standard reference complex mixtures. The complex mixtures used in the study were selected from standard reference materials (SRMs) which had previously been issued by the U.S. NIST as SRMs 1597 (coal tar), SRMs 1649 (diesel particulate matter) and SRMs 1650 (urban air particulate matter) with certified values for polycyclic aromatic hydrocarbons. |
| Supplementary Notes |
Pub. in Mutation Research, v276 n1 p3-9, 1 Jan 92. See also PB91-154096. Prepared in cooperation with Pittsburgh Univ., PA. Dept. of Environmental and Occupational Health, Ford Motor Co., Dearborn, MI. Scientific and Research Lab., National Inst. of Environmental Health Sciences, Research Triangle Park, NC., and National Inst. of Public Health, Tokyo (Japan). |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Design and Implementation of a Collaborative Study of the Mutagenicity of Complex Mixtures in 'Salmonella typhimurium'. |
| Category Codes |
57Y; 57F; 68G; 68A |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/10 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
211522823 |
| Origin |
NTIS |
| Type |
CAT |
