| Main Title |
Pharmacokinetics in Risk Assessment: Drinking Water and Health. Volume 8. |
| CORP Author |
National Research Council, Washington, DC.;Environmental Protection Agency, Washington, DC.;National Institutes of Health, Bethesda, MD. |
| Publisher |
1987 |
| Year Published |
1987 |
| Report Number |
ISBN-0-309-03775-1; EPA-68-01-3169 ;EPA-68-02-3809; |
| Stock Number |
PB89-203319 |
| Additional Subjects |
Potable water ;
Water treatment ;
Meetings ;
Pharmacokinetics ;
Mathematical models ;
Toxicity ;
Epidemiology ;
Risk assessment ;
Toxic substances ;
Dose-response relationships ;
Safe Drinking Water Act of 1974
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB89-203319 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
497p |
| Abstract |
Contents: Risk assessment: historical perspectives; Tissue dosimetry in risk assessment; Modeling: an introduction; Physiologically based pharmacokinetic modeling; Allometry: body size constraints in animal design; Prediction of in vivo parameters of drug metabolism and distribution from in vitro studies; Dose, species, and route extrapolation; Uncertainty in pharmacokinetic models using SIMUSOLV; Interspecies and dose-route extrapolations; Carcinogen DNA-adducts as a measure of biological dose for risk analysis of carcinogenic data; Resources available for simulation in toxicology; Route-to-route extrapolation of dichloromethane exposure using a physiological pharmacokinetic model; Sensitivity analysis in pharmacokinetic modeling; Mutation accumulation: chronic cytotoxicant exposure; Model for ethylene chloride and its application in risk assessment; Mathematical modeling of ozone absorption in the lower respiratory tract; Development of a physiologically based pharmacokinetic model for multiday inhalation of carbon tetrachloride; The delivered/administered dose relationship and its impact on formaldehyde risk estimates; Pharmacokinetic simulation in risk assessment; Hazard assessment: ozone; Role of pharmacokinetic modeling in risk assessment; Development of multispecies, multiroute pharmacokinetic models for methylene chloride and 1,1,1-trichloroethane (methyl chloroform); Methotrexate: pharmacokinetics and assessment of toxicity; Prospective predictions and validations in anticancer therapy; The application of pharmacokinetic data in carcinogenic risk assessment. |
| Supplementary Notes |
See also Volume 4, PB82-249244. Errata sheet inserted. Library of Congress catalog card no. 77-89284. Sponsored in part by contract EPA-68-02-3869 and grants PHS-RR-01693 and PHS-CA-14236. Sponsored by Environmental Protection Agency, Washington, DC., and National Institutes of Health, Bethesda, MD. |
| Category Codes |
57U#; 57Y; 68G#; 68D |
| NTIS Prices |
PC A21/MF A01 |
| Primary Description |
100/00 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
927224941 |
| Origin |
NTIS |
| Type |
CAT |
