Main Title |
SCE and Meitotic Crossover Exchange in Germ Cells. |
Author |
Allen, James W. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
Year Published |
1983 |
Report Number |
EPA-600/D-83-090; |
Stock Number |
PB83-242925 |
Additional Subjects |
Germ cells ;
Toxicology ;
Mice ;
Reproductive system ;
In vivo analysis ;
Chromosomes ;
Mutagenesis ;
Carcinogenesis ;
SCE induction ;
Crossing over
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB83-242925 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
31p |
Abstract |
Mouse spermatogonial cells can be evaluated for SCE induction after in vivo exposure to chemical mutagens and carcinogens. In this system, cyclophosphamide and ethyl carbamate have been shown to cause significant increases in SCE which, however, tend to be lower in magnitude than those expressed by various somatic tissues. Armenian hamster meiotic chromosomes can be evaluated for normal levels of SCE, and both quantitative and qualitative aspects of crossover exchange. Alternate crossover exchange patterns appear directly related to chiasmata in primary spermatocyte sex bivalents, and also are detectable in sex chromosomes from secondary spermatocytes. Thus, high resolution chromatid exchange analysis is versatile in its application for studies of various forms of normal and abnormal genetic recombination processes in mammalian germ cells. |
PUB Date Free Form |
1983 |
Category Codes |
6T; 6C; 57Y; 57F |
NTIS Prices |
PC A03/MF A01 |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
332921218 |
Origin |
NTIS |
Type |
CAT |