| Main Title |
Elimination of Urinary Cotinine in Children Exposed to Known Levels of Side-Stream Cigarette Smoke. |
| Author |
Goldstein, G. M. ;
Collier, A. ;
Etzel, R. ;
Lewtas, J. ;
Haley, N. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;North Carolina Univ. at Chapel Hill. ;Centers for Disease Control, Atlanta, GA. ;American Health Foundation, Inc., Valhalla, NY. Naylor Dana Inst. for Disease Prevention. |
| Year Published |
1987 |
| Report Number |
EPA/600/D-87/087; |
| Stock Number |
PB87-174801 |
| Additional Subjects |
Smoke ;
Tobacco ;
Children ;
Nicotine ;
Exposure ;
Toxicity ;
Urine ;
Cotinine ;
Health risks ;
Drug dose response relationship ;
Side stream smoke ;
Cigarette smoking
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB87-174801 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
11p |
| Abstract |
The establishment of a quantitative personal marker of side-stream smoke exposure in children is important in the study of potential health effects in the group. Cotinine, a metabolite of nicotine, has been shown to exhibit a dose-response relationship to side-stream smoke exposure in adults, and has been used to quantitate prior exposure. The study was undertaken to determine the dose of nicotine, the peak level of urinary cotinine, the time to peak cotinine levels, and the elimination half-life of cotinine in young children exposed to a controlled amount of side-stream smoke. With an exposure to 26.4 ug/cu m of nicotine, nine children averaging 2.03 years old had peak cotinine/creatinine levels of 818 ng/mg. The time to peak cotinine was 4.1 hours, with an elimination half-life of 3.6 hours. |
| Supplementary Notes |
Prepared in cooperation with North Carolina Univ. at Chapel Hill, Centers for Disease Control, Atlanta, GA., and American Health Foundation, Inc., Valhalla, NY. Naylor Dana Inst. for Disease Prevention. |
| PUB Date Free Form |
Mar 87 |
| Category Codes |
57Y |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
718319664 |
| Origin |
NTIS |
| Type |
CAT |
