Main Title |
Transcriptional Changes in Hepatic Tumors of Rats Induced by Di(2-ethylhexyl) phthalate and Di-n-Octyl phthalate. |
Author |
Kandala, J. C. ;
DeAngelo, A. B. ;
Reddy, T. V. ;
Daniel, F. B. ;
Guntaka., R. V. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;Missouri Univ.-Columbia. |
Publisher |
c1993 |
Year Published |
1993 |
Report Number |
EPA/600/J-94/198; |
Stock Number |
PB94-163771 |
Additional Subjects |
Experimental liver neoplasms ;
Genetic transcription ;
Toxicity ;
Diethylhexyl phthalate ;
Oncogenes ;
Ribonucleic acids ;
Gene expression ;
Nucleic acid hybridization ;
Albumins ;
Cytochrome P-450 ;
Aldehyde dehydrogenase ;
Ornithine decarboxylase ;
Reprint ;
Di-n-octyl phthalate
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB94-163771 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
15p |
Abstract |
Di(2-ethylhexyl) phthalate (DEHP) and di-n-octyl phthalate (DOP) are nongenotoxic carcinogens found in drinking water, which induce mainly liver tumors. The mechanism of tumorigenesis by these chemicals remains to be elucidated. The present study was undertaken to test whether any known oncogenes are activated in DEHP- and DOP-induced tumors. The authors examined tumor and chemically treated rat liver RNAs for elevated expression of 10 different oncogenes: c-myc, c-fos, c-Ha-ras, c-Ki-ras, c-raf-l, c-jun, erbA, v-bas, v-sis and v-src. As controls, they used tissue-specific genes such as albumin, cytochrome P450, aldehyde dehydrogenase, and ornithine decarboxylase. Their results indicated that the expression pattern of oncogenes and other genes in chemically treated livers or tumors was not greatly different from that of controls, although in individual livers, multiple changes in transcription were detected. Recently, the authors isolated two genes from a hepatoma cell line by subtraction hybridization. |
Supplementary Notes |
Pub. in Jnl. of Environmental Science v2 n3 p147-159 Jul 93. Prepared in cooperation with Missouri Univ.-Columbia. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Transcriptional Changes in Hepatic Tumors of Rats Induced by Di(2-ethylhexyl) phthalate and Di-n-Octyl phthalate. |
Category Codes |
57Y; 57F |
NTIS Prices |
PC A03/MF A01 |
Primary Description |
600/10 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
416823423 |
Origin |
NTIS |
Type |
CAT |