| Main Title |
Molecular and Cytogenetic Analysis of Lung Tumor Cell Lines. |
| Author |
Hozier, J. ;
|
| CORP Author |
Florida Inst. of Tech., Melbourne.;Health Effects Research Lab., Research Triangle Park, NC. |
| Publisher |
Mar 90 |
| Year Published |
1990 |
| Report Number |
EPA-R-813944; EPA/600/1-90/004; |
| Stock Number |
PB90-183443 |
| Additional Subjects |
Pulmonary neoplasms ;
Cytology ;
Lymphocytes ;
Tables(Data) ;
Cells ;
Chromosomes ;
Molecular structure ;
Ribonucleic acids ;
Deoxyribonucleic acids ;
Genetic mapping ;
DNA probes ;
Nucleic acid hybridization ;
Oncogenes ;
Cultured tumor cells ;
Karyotyping
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB90-183443 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
53p |
| Abstract |
The report measures the levels of amplification of oncogenes and tumor marker genes or other genes of interest in nine human lung tumor cell lines in comparison to normal human bronchial epithelial cells or normal blood lymphocytes to test the hypothesis that aberrant amplification of marker genes may be related to their proximity on the human genome to oncogenes similarly amplified during the development of malignancy. Six pairs of comapping genes and an additional unpaired oncogene were used for analysis: the oncogenes MYCL and BLYM, KRASIP and prolactin; KRASIP and chronic gonadotropin, alpha chain; MYB and chorionic gonadotropin, alpha chain; MYC and thyroglobulin; FOS and creatine kinase, brain form, and MUCN. Of 31 gene pairs tested, amplification was observed in three cases. In two out of those three, co-amplification was observed in the MYC gene and the closely mapping thyroglobulin gene. |
| Supplementary Notes |
Portions of this document are not fully legible. Sponsored by Health Effects Research Lab., Research Triangle Park, NC. |
| NTIS Title Notes |
Technical rept. |
| Category Codes |
57F; 57E |
| NTIS Prices |
PC A04/MF A01 |
| Primary Description |
600/10 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
011720195 |
| Origin |
NTIS |
| Type |
CAT |
