| Main Title |
Inhibition of Intercellular Communication between Mouse Hepatocytes by Tumor Promoters. |
| Author |
Ruch, R. J. ;
Klaunig, J. E. ;
Pereira, M. A. ;
|
| CORP Author |
Health Effects Research Lab., Cincinnati, OH. ;Medical Coll. of Ohio at Toledo. |
| Year Published |
1987 |
| Report Number |
EPA/600/J-87/016; |
| Stock Number |
PB87-196218 |
| Additional Subjects |
Carcinogens ;
Pharmacology ;
Methyl sulfoxide ;
Cytology ;
Liver ;
DDT ;
Phenobarbital ;
Ribonucleic acids ;
Neoplasms ;
Uridine ;
Cells ;
Reprints ;
Cell communication ;
Aroclors ;
Benzene hexachloride ;
Dimethyl sulfoxide
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB87-196218 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
12p |
| Abstract |
Tumor promoters can inhibit gap junction-mediated intercellular communication in cultured cells. The authors evaluated the effects of tumor promoters on intercellular communication between B6C3F1 mouse hepatocytes in primary culture. Intercellular communication between donor and recipient hepatocytes was detected as an increase in autoradiographic grains over recipient cells in contact with donor cells, indicating the passage of labeled nucleotides from donor to recipient hepatocytes. Intercellular communication in untreated and solvent vehicle treated hepatocytes was detected in approximately 80% of the donor-contacting recipients after 8-12 hr culture. Phenobarbital, DDT, Aroclor 1254, lindane, and TPA significantly decreased hepatocyte intercellular communication in a dose-dependent manner. (Copyright (c) 1987 by Academic Press, Inc.) |
| Supplementary Notes |
Pub. in Toxicology and Applied Pharmacology, v87 n1 p111-120 Jan 87. Prepared in cooperation with Medical Coll. of Ohio at Toledo. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Inhibition of Intercellular Communication between Mouse Hepatocytes by Tumor Promoters. |
| PUB Date Free Form |
c1987 |
| Category Codes |
57B; 57F; 57Q; 57Y |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
723225541 |
| Origin |
NTIS |
| Type |
CAT |
