| Main Title |
Dopamine Depletion Slows Retinal Transmission. |
| Author |
Dyer, Robert S. ;
Howell, William E. ;
MacPhail, Robert C. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
| Year Published |
1981 |
| Report Number |
EPA-600/J-80-014; |
| Stock Number |
PB82-127432 |
| Additional Subjects |
Norepinephrine ;
Eye(Anatomy) ;
Retina ;
Depletion ;
Reprints ;
Dopamine
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB82-127432 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
17p |
| Abstract |
In male hooded rats, depletion of norepinephrine and dopamine by a-methyl-paratyrosine (AMT) significantly increased the latencies of early peaks in flash-evoked potentials recorded from the visual cortex, lateral geniculate nucleus, and optic tract. These effects were not produced by depletion of norepinephrine by FLA-63, blockade of muscarinic acetylcholine receptors by scopolamine, or blockade of opiate receptors by naloxone. AMT effects occurred only when flashes were used; optic tract stimulation failed to reveal the drug-induced changes. In a dose-response study, haloperidol produced effects similar to those of AMT. L-Dopa + R04-4602 reversed some of the effects of AMT. It is concluded that depletion of retinal dopamine impairs the timing of retinal responses to light. |
| Supplementary Notes |
Pub. in Experimental Neurology 71, p326-340 1981. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Dopamine Depletion Slows Retinal Transmission. |
| PUB Date Free Form |
Sep 81 |
| Category Codes |
6P; 57S |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
323807662 |
| Origin |
NTIS |
| Type |
CAT |
