| Main Title |
Differences in Inflammatory Responses to Exposures of Concentrated Ambient Particles in Susceptible Volunteers. |
| Author |
M. A. Riedl ;
W. S. Linn ;
K. W. Clark ;
D. Diaz-Sanchez
|
| CORP Author |
California Univ., Los Angeles.; California State Air Resources Board, Sacramento.; California Environmental Protection Agency, Sacramento. |
| Year Published |
2010 |
| Report Number |
CARBRA-05-341 |
| Stock Number |
PB2010-110811 |
| Additional Subjects |
Particulates ;
Air pollution ;
Human health ;
Environmental exposure ;
Health effects ;
Response ;
Cardiopulmonary ;
Biomarkers ;
Respiratory system ;
Tables(Data) ;
Asthma ;
Physiology ;
Inflammation ;
Monitoring ;
Regulations ;
Symptoms
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB2010-110811 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
84p |
| Abstract |
Respirable particulate matter (PM) is associated with harmful cardiopulmonary effects in humans. To test the hypothesis that individuals with certain susceptibility factors have heightened inflammatory and airway responses to PM exposure, a single-blind randomized dose crossover human study of controlled exposure to filtered air (FA), and concentrated ambient particles (CAPS) was conducted. We enrolled 10 mild- moderate asthmatic GSTMI null subjects, 10 mild- moderate asthmatic GSTMI present subjects and 10 healthy GSTMI present subjects to determine the short-term effects of CAPS exposure in individuals likely to be at risk for adverse effects. Outcome measures included symptom scores, physiologic measures (vital signs, spirometry, exhaled nitric oxide, heart rate variability) as well as serum, sputum, and nasal lavage samples for inflammatory biomarkers. |
| Supplementary Notes |
Sponsored by California State Air Resources Board, Sacramento. and California Environmental Protection Agency, Sacramento. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5301 Shawnee Road, Alexandria, VA, 22312, USA. |
| PUB Date Free Form |
Apr 2010 |
| Category Codes |
68A; 68G; 57E |
| NTIS Prices |
PC A06/MF A06 |
| Document Type |
NT |
| Medium |
Final rept |
| Cataloging Source |
NTIS/MT |
| Control Number |
128600730 |
| Origin |
NTIS |
| Type |
CAT |
