| Main Title |
Cancer Dose-Response Models Incorporating Clonal Expansion. |
| Author |
Chen, C. W. ;
Moini, A. ;
|
| CORP Author |
Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment. ;Computer Sciences Corp., Arlington, VA. |
| Publisher |
Oct 89 |
| Year Published |
1989 |
| Report Number |
EPA/600/D-91/042 ;OHEA-C-330; |
| Stock Number |
PB91-171975 |
| Additional Subjects |
Carcinogenesis ;
Dose-response relationships ;
Mathematical models ;
Risk factors ;
Predictive value of tests ;
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB91-171975 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
26p |
| Abstract |
Under the assumption that a malignant tumor develops through a sequence of steps (normal cells->initiated cells/foci->nodules->tumors) two classes of mathematical models of carcinogenesis that have a potential to be used for cancer dose-response modeling are discussed. The two classes of models considered are (1) a general version of the two-stage model by Moolgavkar and colleagues, henceforth called the MVK model, and (2) a clone process model derived from Tucker. These two classes of models incorporate essentially the same biological information but in different ways and offer a conceptual contrast between the two differing approaches. The objectives of the paper are to (1) highlight issues and problems that arise in using biologically based dose-response models to predict cancer risk and (2) discuss how parameters in the models could be estimated using auxiliary information. |
| Supplementary Notes |
Presented at the Research Application Conference on Scientific Issues in Quantitative Cancer Risk Assessment, Arlington, VA., October 1989. Prepared in cooperation with Computer Sciences Corp., Arlington, VA. |
| NTIS Title Notes |
Symposium paper. |
| Category Codes |
57E; 57Y |
| NTIS Prices |
PC A03/MF A01 |
| Primary Description |
600/21 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
116426153 |
| Origin |
NTIS |
| Type |
CAT |
