| Main Title |
Auditory Deficits and Motor Dysfunction Following Iminodipropionitrile Administration in the Rat. |
| Author |
Crofton, K. M. ;
Knight, T. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div. ;North Carolina Central Univ., Durham. Dept. of Biology. |
| Publisher |
c1991 |
| Year Published |
1991 |
| Report Number |
EPA/600/J-92/017; |
| Stock Number |
PB92-143890 |
| Additional Subjects |
Animal behavior ;
Audiometry ;
Motor activity ;
Toxicology ;
Startle reaction ;
Reflexes ;
Dose-response relationships ;
Body weight ;
Reprints ;
Iminodipropionitriles
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB92-143890 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
9p |
| Abstract |
The behavioral effects of 3,3'-iminodipropionitrile (IDPN) were studied using reflex modification of the acoustic startle response and figure-eight maze activity. A number of experiments were conducted with separate groups of adult male Long-Evans hooded rats exposed to saline or 50-500 mg/kg IDPN for 3 consecutive days. Auditory thresholds (reflex modification), motor activity, and grip strength were measured 1 day, and 1, 3, and 9 weeks postdosing. Reflex inhibition was monitored daily, prior to, during, and for 7 days following exposure. Auditory thresholds for 5- and 40-kHz tones were elevated approximately 25 dB and 50 dB, respectively. The onset of the auditory dysfunction in the 200-mg/kg/day group, as demonstrated by a loss of reflex inhibition, was 2 days for the 40-kHz tone and 4 days for the 5-kHz tone. Motor activity was increased up to 400% in the 200-mg/kg group, whereas there was no alteration in hindlimb grip strength. These data demonstrate dosage- and time-dependent alterations in auditory and motor function following IDPN exposure. |
| Supplementary Notes |
Pub. in Neurotoxicology and Teratology, v13 n6 p575-581 Nov 91. See also PB91-145078. Prepared in cooperation with North Carolina Central Univ., Durham. Dept. of Biology. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Auditory Deficits and Motor Dysfunction Following Iminodipropionitrile Administration in the Rat. |
| Category Codes |
57Y; 57S |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/10 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
208728723 |
| Origin |
NTIS |
| Type |
CAT |
