Main Title |
Applications of an Exact NOAEL (No-Observed-Adverse-Effect-Level) Procedure for Dichotomous Data from Animal Experiments. |
CORP Author |
Brown (Kenneth G.), Chapel Hill, NC.;Environmental Protection Agency, Cincinnati, OH. Environmental Criteria and Assessment Office. |
Publisher |
Nov 89 |
Year Published |
1989 |
Report Number |
EPA-68-01-6826; EPA/600/8-89/068; |
Stock Number |
PB90-145780 |
Additional Subjects |
Mathematical models ;
Toxicity ;
Dosimetry ;
Graphs(Charts) ;
Exposure ;
Animals ;
No-observed-adverse-effects-level ;
Dose-response relationships ;
Risk assessment ;
False negative reactions
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB90-145780 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
49p |
Abstract |
A statistical method has been developed that utilizes a step-wise hypothesis testing procedure to estimate the distribution of the no-observed-adverse-effect level (NOAEL), and thereby to estimate the expected value of the NOAEL and its variability. The methodology is dependent upon the sum of the dose group sizes, the expected response rates, experimental dose levels, and the type I error rates. The technique may be employed to evaluate the reliability of the NOAEL and to provide a measure of its variability. |
Supplementary Notes |
Sponsored by Environmental Protection Agency, Cincinnati, OH. Environmental Criteria and Assessment Office. |
Category Codes |
57Y |
NTIS Prices |
PC A03/MF A01 |
Primary Description |
600/22 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
007530264 |
Origin |
NTIS |
Type |
CAT |