| Main Title |
Application and assessment of neurobehavioral methods in rats / |
| Author |
Moser, Virginia C.
|
| Other Authors |
|
| CORP Author |
NSI Technology Services Corp., Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC. |
| Publisher |
U.S. Environmental Protection Agency, Office of Research and Development, Health Effects Research Laboratory, |
| Year Published |
1989 |
| Report Number |
EPA/600/D-89/139 |
| Stock Number |
PB90-113192 |
| Additional Subjects |
Animal behavior ;
Graphs(Charts) ;
Tables(Data) ;
Motor activity ;
Neurotoxins ;
Tests ;
Risk assessment ;
Dose-response relationships
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB90-113192 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
29 pages ; 28 cm |
| Abstract |
The majority of chemicals present in the environment have not received adequate testing to determine their neurotoxic potential. Thus, the US EPA has prepared guidelines for neurotoxicity testing for both new and existing chemicals. Based on these guidelines, a core battery of tests to assess the behavioral and neurological integrity of laboratory rats was developed for use in the primary screening of chemicals. The study systematically applies the FOB and MA to characterize known neurotoxicants and to assess sensitivity, reliability, selectivity, and specificity of the tests. The FOB includes home-cage and open-field observations, and neuromuscular, sensorimotor, and physiological measures. MA is measured in an automated photocell device (figure-eight maze). The tests have been demonstrated to be sensitive to a variety of neurotoxicants, and profiles of effects can be established to distinguish between them. The data provide important information on the feasibility and interpretation of functional evaluations in the hazard identification of neurotoxic chemicals. |
| Notes |
Includes bibliographical references. "EPA/600/D-89/139"--Cover. "Presented at the Proceedings of the Third International Symposium on Neurobehavioral Methods in Occupational and Environmental Health." Microfiche. |
| Place Published |
Research Triangle Park, NC : |
| Supplementary Notes |
Presented at the International Symposium on Neurobehavioral Methods in Occupational and Environmental Health (3rd), Washington, DC., December 12-15, 1988. Sponsored by Health Effects Research Lab., Research Triangle Park, NC. |
| Corporate Au Added Ent |
United States. Environmental Protection Agency. Office of Research and Development. ; Health Effects Research Laboratory. |
| PUB Date Free Form |
{1989} |
| NTIS Prices |
PC A03/MF A01 |
| BIB Level |
m |
| Cataloging Source |
OCLC/T |
| OCLC Time Stamp |
20001006121620 |
| Language |
eng |
| Origin |
NTIS |
| Type |
MERGE |
| OCLC Rec Leader |
01254nam 2200277Ka 45020 |
