| Main Title |
Use of Carbon Dioxide Challenge to Detect Toxicant - Induced Changes in Cardiopulmonary Function of Awake Rats. |
| Author |
Tepper, J. S. ;
Wiester, M. J. ;
King, M. E. ;
Weber, M. F. ;
Costa., D. L. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. Toxicology Branch. ;Northrop Services, Inc., Research Triangle Park, NC. |
| Publisher |
c1988 |
| Year Published |
1988 |
| Report Number |
EPA/600/J-88/550; |
| Stock Number |
PB91-116038 |
| Additional Subjects |
Toxicology ;
Carbon dioxide ;
Rats ;
Reprints ;
Heart function tests ;
Respiratory function tests ;
Air pollution effects(Animals) ;
Computer applications ;
Wakefulness ;
Hemodynamics
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB91-116038 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
19p |
| Abstract |
A system has been developed to measure simulatneously the effects of inhaled toxicants on cardiopulmonary function in four awake rats before, during and after exposure. One day prior to testing, Fischer-344 and Sprague-Dawley rats were implanted with an intrapleural or carotid catheter. On the day of testing, the rats were placed into a restraint system to reduce movement artifacts and to keep rats from disturbing the implanted catheters without imposing limitations on functional measurements. The rats were then sealed into constant-volume plethysmographs mounted on the door of a 0.32-cu m Rochester exposure chamber. Thirty minutes after the rats were placed into the plethysmographs, control measurements were obtained. Under the control of a digital computer, the rats were exposed for 15-min periods to 4% CO2. During testing, tidal volume, intrapleural pressure, blood pressure, and the electrocardiogram were recorded on the polygraph, and were digitized and stored in the computer. Four-second breathing epochs were recorded and analyzed, and the results were displayed on line. |
| Supplementary Notes |
Inhalation Toxicology, Premier Issue, p79-95, Oct 88. Prepared in cooperation with Northrop Services, Inc., Research Triangle Park, NC. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Use of Carbon Dioxide Challenge to Detect Toxicant - Induced Changes in Cardiopulmonary Function of Awake Rats. |
| Category Codes |
57Y; 57S; 68A |
| NTIS Prices |
PC A03/MF A01 |
| Primary Description |
600/10 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
101123366 |
| Origin |
NTIS |
| Type |
CAT |
