| Main Title |
Distribution and Toxicological Effects of Inhaled Methyl Bromide in the Rat. |
| Author |
Jaskot, R. H. ;
Grose, E. C. ;
Most, B. M. ;
Menache, M. G. ;
Williams, T. B. ;
|
| CORP Author |
Northrop Services, Inc./Environmental Sciences, Research Triangle Park, NC. Inhalation Toxicology Group. ;National Inst. of Environmental Health Sciences, Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC. |
| Publisher |
c1988 |
| Year Published |
1988 |
| Report Number |
EPA-68-02-4032; EPA/600/J-88/543; |
| Stock Number |
PB91-109249 |
| Additional Subjects |
Toxicology ;
Rats ;
Laboratory animals ;
Exhaust emissions ;
Public health ;
Biochemistry ;
Liver diseases ;
Respiratory diseases ;
Necrosis ;
Carbon 14 ;
Reprints ;
Methyl bromide ;
Inhalation ;
Air pollution effects(Humans)
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB91-109249 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
14p |
| Abstract |
Sixty day old male CD rats were exposed by nose only to (14)C-methyl bromide (55 ppm) for three minutes. The data indicated that the liver, lung, and kidney were the major organs of (14)C deposition immediately following exposure. Up to thirty-two hours following exposure, the major routes of excretion were pulmonary (14CO2) and renal with approximately 43% and 21% of the total inhaled radiolabel being eliminated, respectively. In separate experiments, 60 day old CD male rats were exposed by whole body inhalation for 6 hours/day for 1, 5, and 10 days to 30 ppm methyl bromide or control air. Following the 1 day exposure, glutathione (GSH) reductase activity in the liver showed an increase, while GSH S-transferase was significantly increased. Glucose-6-dehydrogenase (G-6-PDH) was increased and nonprotein sulfhydryl content was decreased in the kidney. After 5 days of exposure, GSH transferase activity was significantly increased, while G-6-PDH showed an increase in the lung. GSH reductase activity had decreased in the liver. After 10 days of exposure an increase in G-6-PDH activity was evident in the lung, and a significant decrease in GSH reductase and GSH S-transferase activities were found in the liver. |
| Supplementary Notes |
Pub. in Jnl. of the American College of Toxicology, v7 n5 p631-641 1988. Prepared in cooperation with National Inst. of Environmental Health Sciences, Research Triangle Park, NC. Sponsored by Health Effects Research Lab., Research Triangle Park, NC. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Distribution and Toxicological Effects of Inhaled Methyl Bromide in the Rat. |
| Category Codes |
57Y; 57U; 57B; 68G; 68A |
| NTIS Prices |
PC A03/MF A01 |
| Primary Description |
600/10 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
034834412 |
| Origin |
NTIS |
| Type |
CAT |
