Main Title |
Organochlorine compounds in relation to breast cancer, endometrial cancer, and endometriosis : an assessment of the biological and epidemiological evidence / |
Author |
Ahlborg, Ulf G.,
|
Other Authors |
Author |
Title of a Work |
Lipworth, Loren., |
Titus-Ernstoff, Linda., |
Hsieh, Chung-Cheng., |
Hanberg, Annika., |
Baron, John., |
Trichopoulos, Dimitrios., |
Adami, Hans-Olov., |
|
Publisher |
CRC Press, Inc., |
Year Published |
1995 |
OCLC Number |
878677675 |
Subjects |
Breast--Cancer--United States ;
Pesticides--Environmental aspects ;
Pesticide residues in food--United States ;
Pesticides--Physiological effect--United States ;
Estrogen--Physiological effect ;
Insect chemosterilization--United States ;
Pesticides--Environmental aspects--United States ;
Organochlorine compounds--Toxicology ;
Pesticides--United States--Physiological effect
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
ESAM |
RC280.B8.O74 1995 |
|
Region 10 Library/Seattle,WA |
05/06/2014 |
|
Collation |
68 unnumbered pages : illustrations ; 28 cm |
Notes |
Includes bibliographical references (pages 515-531) Caption title. |
Contents Notes |
There is an increasing public and scientific concern that certain chlorinated compounds, recognized as environmental pollutants, may cause estrogen-related neoplastic disease in humans. The main hypothesis has been that certain organochlorines, through their estrogenic actions, might cause breast cancer. From experimental studies, both in vitro and in vivo, there is evidence that certain organochlorine compounds may cause estrogenic effects, whereas others may cause antiestrogenic effects. In limited studies, some of these compounds in high doses have also been shown to increase and reduce the frequency of estrogen-related tumors in animals. The epidemiological findings regarding the association between organochlorines and breast cancer are inconclusive. However, the largest and best designed study has been interpreted as negative with respect to DDT and polychlorinated biphenyls (PCB) in relation to breast cancer. Associations between organochlorine exposure and endometrial cancer or endometriosis have even more limited empirical basis. The hypothesis that human exposure to environmental levels of organochlorines would favor an estrogenic overactivity leading to an increase in estrogen-dependent formation of mammary or endometrial tumors is not supported by the existing in vitro, animal and epidemiological evidence. It can, however, not be conclusively rejected on the basis of available data. |
Place Published |
Boca Raton, Florida |
Corporate Au Added Ent |
CRC Press, Inc., |
Title Ser Add Ent |
Critical reviews in toxicology ; 25(6) |
PUB Date Free Form |
1995 |
Series Title Untraced |
Critical reviews in toxicology ; 25(6) |
BIB Level |
m |
Medium |
unmediated |
Content |
text |
Carrier |
volume |
Cataloging Source |
RDA |
OCLC Time Stamp |
20140430110630 |
Language |
eng |
Origin |
OCLC |
Type |
CAT |
OCLC Rec Leader |
03379nam 2200481Ki 45020 |