| Main Title |
Distribution of 2,4,5-Trichlorophenoxyacetic Acid in the Mouse Fetus. |
| Author |
Courtney, K. D. ;
Brown, M. T. ;
Tucker., A. W. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, N.C. Experimental Biology Div. |
| Year Published |
1977 |
| Report Number |
EPA/600/J-77/125; |
| Stock Number |
PB-284 757 |
| Additional Subjects |
Pesticides ;
Herbicides ;
Toxicology ;
Pathology ;
Tables(Data) ;
Chlorine organic compounds ;
Mice ;
Laboratory animals ;
Experimental data ;
Excretion ;
Urine ;
Concentration(Composition) ;
Tissues(Biology) ;
Autoradiography ;
Brain ;
Liver ;
Eye(Anatomy) ;
Distribution ;
Muscles ;
Skin(Anatomy) ;
Reprints ;
Fetus ;
T 2-4-5 herbicide ;
Acetic acid/trichlorophenoxy ;
Toxic substances ;
Pesticide residues
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB-284 757 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
7p |
| Abstract |
The herbicide 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) readily crosses the placenta in the mouse on gestational day 13. Concentrations of 2,4,5-T in maternal tissues and fetuses were obvious at 30 min., highest at 8 h, diminished by 24 h and almost entirely eliminated by 48 h. Autoradiographs of the whole fetus showed that initially 2,4,5-T was mainly in the highly vascularized tissues such as liver followed by the skin, eyes and ventricles of the brain. At 48 h, there was a general distribution of 2,4,5-T in the skeletal muscles. None was detected in the palate. The excretion rate in the mouse was approximately 60 micrograms/h; about 52% of the dose was recovered unchanged in the urine in 24 h. |
| Supplementary Notes |
Pub. in Toxicology Letters, v1 p103-108. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Distribution of 2,4,5-Trichlorophenoxyacetic Acid in the Mouse Fetus. |
| PUB Date Free Form |
19 May 77 |
| Category Codes |
6T; 6F; 57Y; 68E |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
323746185 |
| Origin |
NTIS |
| Type |
CAT |
