| Main Title |
Use of 'In vitro' Methods for Assessing Reproductive Toxicity, Dichlorophenols. |
| Author |
Seyler, D. E. ;
East, J. M. ;
Condie, L. W. ;
Borzelleca, J. F. ;
|
| CORP Author |
Medical Coll. of Virginia, Richmond. Dept. of Pharmacology. ;Georgetown Univ., Washington, DC.;Health Effects Research Lab., Research Triangle Park, NC. |
| Year Published |
1984 |
| Report Number |
EPA-R-808861; EPA/600/J-84/127; |
| Stock Number |
PB85-113975 |
| Additional Subjects |
In vitro analysis ;
Toxicity ;
Phenols ;
Reproductive system ;
Laboratory animals ;
Public health ;
Assessments ;
Concentration(Composition) ;
Chlorine organic compounds ;
Dosage ;
Reprints ;
Phenol/dichloro
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB85-113975 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
11p |
| Abstract |
Environmental levels of dichlorophenols (DCPs) appear to be increasing. A paucity of knowledge exists concerning the impact of these agents on human health, including reproductive effects. Mice are being exposed to various DCPs to determine their toxic potential. In addition, the mouse in vitro fertilization method ass used to evaluate the potential reproductive effects of series of DCPs. This method is preliminary reproductive screening procedure. In vitro penetration was depressed by 2,5-DCP, 3,4-DCP, and 3,5-DCP. None of the agents affected sperm motility. Acridine orange fluorescent microscopy revealed that 3,4-DCP and 3,5-DCP disrupted the sperm acrosome; this could result in depressed penetration. |
| Supplementary Notes |
Prepared in cooperation with Georgetown Univ., Washington, DC. |
| Availability Notes |
Pub. in Toxicology Letters 20, p309-315 1984. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Use of 'In vitro' Methods for Assessing Reproductive Toxicity, Dichlorophenols. |
| PUB Date Free Form |
c1984 |
| Category Codes |
6T; 6E; 68G; 57U; 57Y |
| NTIS Prices |
Not available NTIS |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
501827008 |
| Origin |
NTIS |
| Type |
CAT |
