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Main Title Overview, Conclusions, and Recommendations of the IPCS Collaborative Study on Complex Mixtures.
Author Claxton, L. D. ; Douglas, G. ; Krewski, D. ; Lewtas, J. ; Matsushita, H. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Health and Welfare Canada, Ottawa (Ontario). ;National Inst. of Public Health, Tokyo (Japan). ;Pittsburgh Univ., PA.
Publisher c1992
Year Published 1992
Report Number EPA/600/J-92/054;
Stock Number PB92-150689
Additional Subjects Mutagens ; Toxic substances ; Mixtures ; Bioassay ; Salmonella typhimurium ; Reproducibility of results ; Interlaboratory comparisons ; SOS response(Genetics) ; Mutagenicity tests ; Metabolic activation ; Reprints ; Standard Reference Materials
Library Call Number Additional Info Location Last
NTIS  PB92-150689 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 21p
Abstract The International Programme on Chemical Safety (IPCS) and the U.S. EPA sponsored an international collaborative study to examine the variability associated with the extraction and bioassay of Standard Reference Materials (SRMs) that are complex environmental mixtures provided by the U.S. National Institute of Standards and Technology (NIST). The study evaluated the feasibility of establishing bioassay reference values and ranges for the SRMs. Twenty laboratories from North America, Europe, and Japan participated in the study. The bioassay used was the Salmonella/microsomal plate incorporation assay. Repeatability (intralaboratory variance) of the bioassay results ranged from 16% to 88% depending on the SRM and the bioassay conditions (tester strain and metabolic activation); whereas, reproducibility (interlaboratory variance) ranged from 33% to 152%. Between laboratory variability was the main source of variation accounting for approximately 55% to 95% of the total variation for the three environmental samples. Variation in the mutagenic potency of the control compounds was comparable, although the reproducibility of 1-nitropyrene ranged from 127% to 132%.
Supplementary Notes Pub. in Mutation Research, v276 n2 p61-80 1992. See also PB88-205380. Prepared in cooperation with Health and Welfare Canada, Ottawa (Ontario), National Inst. of Public Health, Tokyo (Japan), and Pittsburgh Univ., PA.
NTIS Title Notes Journal article.
Title Annotations Reprint: Overview, Conclusions, and Recommendations of the IPCS Collaborative Study on Complex Mixtures.
Category Codes 57Y; 57F; 68G
NTIS Prices PC A03/MF A01
Primary Description 600/10
Document Type NT
Cataloging Source NTIS/MT
Control Number 211522814
Origin NTIS
Type CAT