| Main Title |
Host Resistance Models Available for Immunotoxicologic Studies. |
| Author |
Fenters, James D. ;
Aranyi, C. ;
Barbera, P. ;
Bradof, J. ;
Fugmann, R. ;
|
| CORP Author |
IIT Research Inst., Chicago, IL. |
| Year Published |
1983 |
| Report Number |
NIEHS-1-ES15000, EPA-R-8067300; |
| Stock Number |
AD-P001 965/3 |
| Additional Subjects |
Toxicology ;
Immunology ;
Resistance(Biology) ;
Hosts(Biology) ;
Anatomical models ;
Laboratory animals ;
Response(Biology) ;
Toxicity ;
Drugs ;
Chemicals ;
Pollutants ;
Ozone ;
Bacterial diseases ;
Pneumonia ;
Infectious diseases ;
Models ;
Toxic agents ;
Neoplasms ;
Inhalation ;
Mice ;
Hamsters ;
Guinea pigs ;
Squirrel monkeys ;
Immunotoxicology ;
Environmental toxicology ;
Component reports
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
AD-P001 965/3 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
19p |
| Abstract |
For about 25 years various investigators at IIT Research Institute (IITRI) have been developing animal model systems to measure the holistic response to drugs, chemicals, and air pollutants. In 1958, the first report on the effects of ozone (03) on bacterial pneumonia was published by Miller and Ehrlich. That research, supported by the United States Air Force, was the basis for our subsequent programs in which several infectious disease models were used to evaluate the effects of a variety of toxicants. Table 1 shows thirteen infectious disease models and one tumor challenge model we have used in mice, hamsters, guinea pigs, or squirrel monkeys. With the exception of the diethylstilbestrol (DES), all toxicants were administered by the inhalation route. Other investigators are working with a variety of tumor and infectious disease models to evaluate toxicants administered by various routes and Dean et al. (1982b) have summarized this research. As a consequence there is a wide selection of host resistance models available for use. |
| Supplementary Notes |
This article is from 'Proceedings of the Conference on Environmental Toxicology (13th) Held at Dayton, Ohio on 16, 17, and 18 November 1982,' AD-A134 150, p33-51. |
| PUB Date Free Form |
Aug 83 |
| Category Codes |
6T; 6E; 57Y; 57J |
| NTIS Prices |
PC A02/MF A01 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
404813079 |
| Origin |
NTIS |
| Type |
CAT |
