||Value of Multiple Endpoint Data in Male Reproductive Toxicology: Revelations in the Rat (Journal article).
Perreault, S. D. ;
Linder, R. E. ;
Strader, L. F. ;
Slott, V. ;
||Health Effects Research Lab., Research Triangle Park, NC.
Reproductive system ;
Germ cells ;
||Some EPA libraries have a fiche copy filed under the call number shown.
||To explore the relationship between sperm measures and reproductive success in the laboratory rat, results of several male reproductive toxicology studies containing both fertility and multiple endpoint data are reviewed. Comparisons are made between subchronic and acute exposure studies, stressing the value of multiple endpoint data for each approach. In addition, the choice of endpoints in male reproductive toxicology is discussed with emphasis on those endpoints that are still evolving. It is concluded that sperm measures are far more sensitive indicators of reproductive organ impairment than is fertility, and that evaluation of multiple endpoints in acute studies is a key step in determining mechanisms of toxicant action that are critical for interspecies risk extrapolation.
||Pub. in Proceedings of Workshop 'Sperm Measures and Reproductive Success: Institute for Health Policy Analysis Forum on Science, Health, and Environmental Risk Assessment, Queenstown, MD., January 12-14, 1988, p179-192 1989. See also PB88-225024.
||PC A03/MF A01