| Main Title |
Immune Response and Prevalence of Antibody to Norwalk Enteritis Virus as Determined by Radioimmunoassay. |
| Author |
Blacklow, Neil R. ;
Cukor, George ;
Bedigian, Mary Kay ;
Echeverria, Peter ;
Greenberg, Harry B. ;
|
| CORP Author |
Massachusetts Univ. Medical School, Worcester.;Health Effects Research Lab., Cincinnati, OH. |
| Year Published |
1981 |
| Report Number |
EPA-R-805169 ;EPA-R-806591; EPA/600/J-79-128; |
| Stock Number |
PB81-232209 |
| Additional Subjects |
Enteroviruses ;
Viruses ;
Antibodies ;
Reprints ;
Immune responses ;
Radioimmunoassay
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB81-232209 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
9p |
| Abstract |
A solid-phase microtiter radioimmunoassay was established for the detection of Norwalk virus and its antibody, with clinical materials from human volunteers previously studied in Massachusetts as reagents. A study of 308 Massachusetts residents showed that serum antibody to Norwalk agent was rarely present during childhood but was detectable in approximately 50% of adults. All volunteers inoculated with Norwalk virus who developed illness seroconverted (10/10), whereas only one-third (5/15) of nonill volunteers seroconverted (P=0.0009). The 10 nonill, nonseroconverting subjects had undetectable to low preexisting antibody levels. Paradoxically, 10/13 subjects with preexisting antibody became ill, whereas 17/25 lacking antibody did not (P=0.009). All 3 subjects with preexisting anti-Norwalk radioimmunoassay blocking activity in duodenal intraluminal fluids became ill, whereas only 5/11 lacking such activity developed illness (P=0.15). These data further support the unique concept that some individuals are susceptible to repeated infections with this agent, whereas others are incapable of developing infection. |
| Supplementary Notes |
Pub. in Journal of Clinical Microbiology, p903-909 Dec 79. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Immune Response and Prevalence of Antibody to Norwalk Enteritis Virus as Determined by Radioimmunoassay. |
| PUB Date Free Form |
Jul 81 |
| Category Codes |
6E; 6M; 57J; 57K |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/10 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
323802042 |
| Origin |
NTIS |
| Type |
CAT |
