| Main Title |
Quantitative Cancer Risk Assessment Methodology Using Short-Term Genetic Bioassays: The Comparative Potency Method. |
| Author |
Lewtas, J. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
| Year Published |
1985 |
| Report Number |
EPA/600/D-85/237; |
| Stock Number |
PB86-117017 |
| Additional Subjects |
Bioassay ;
Malignant neoplasms ;
Comparison ;
Assessments ;
Risk ;
Quantitative analysis ;
Cancer
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB86-117017 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
17p |
| Abstract |
Quantitative risk assessment is fraught with many uncertainties. The validity of the assumptions underlying the methods employed are often difficult to test or validate. Cancer risk assessment has generally employed either human epidemiological data from relatively high occupational exposures or animal cancer data from lifetime rodent bioassays. Low-dose extrapolation methods are often used with the human epidemiological data to estimate risks at lower environmental exposure levels. Scaling factors are used with animal data to extrapolate from rodents to humans. The problems, controversies, and uncertainties associated with these methodologies has encouraged us to develop the concept and methodology associated with a comparative potency method for cancer risk assessment. This comparative potency method may be particularly appropriate for application to the quantitative cancer risk assessment of combustion emissions. |
| PUB Date Free Form |
Oct 85 |
| Category Codes |
6C; 57F |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
601716279 |
| Origin |
NTIS |
| Type |
CAT |
