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OLS Field Name OLS Field Data
Main Title Effect of 1,3-Dinitrobenzene on Prepubertal, Pubertal, and Adult Mouse Spermatogenesis.
Author Everson, D. P. ; Janca, F. C. ; Baer, R. K. ; Jost, L. K. ; Karabinus, D. S. ;
CORP Author South Dakota State Univ., Brookings. Dept. of Chemistry.
Publisher c1989
Year Published 1989
Report Number EPA-R-810991; EPA/600/J-89/373;
Stock Number PB90-215872
Additional Subjects Toxicology ; Deoxyribonucleic acids ; Mice ; Graphs(Charts) ; Testis ; Body weight ; Tables(Data) ; Reprints ; Dinitrobenzenes ; Spermatogenesis ; Puberty ; Ploidies ; Flow cytometry ; Epididymis ; Chromatin ; Organ weight
Library Call Number Additional Info Location Last
NTIS  PB90-215872 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 08/27/1990
Collation 16p
Abstract Exposure of prepubertal, pubertal, and adult mice to 0, 8, 16, 32, 40, or 48 mg 1,3-dinitrobenzene (m-DNB)/kg body weight and measuring responses 1-25 d posttreatment (dpt) demonstrated significant effects on testicular function only at 48 mg/kg dosage. m-DNB had no effect on body or testis weights with the exception of reduced adult mouse testis weights at 22 dpt with 48 mg/kg (p <.05). None of the exposures resulted in detectable levels of germinal epithelial cells in the ductus epididymis. Exposure of prepubertal and pubertal mice to m-DNB caused only minimal nonsignificant changes in the relative percent of testicular cell types present up to 25 dpt. The adult mice testicular cell type ratios, in particular the round and elongating spermatid populations, changed significantly at doses of 48 mg/kg. Also, a reduction in the percent tetraploid cells occurred at d 1, suggesting these cells may be a primary target of m-DNB action. Caput and caudal sperm from mice exposed to m-DNB prior to puberty did not demonstrate an increased susceptibility to DNA denaturation when analyzed by the sperm chromatin structure assay.
Supplementary Notes Pub. in Jnl. of Toxicology and Environmental Health, v28 p67-80 Sep 89. Health Effects Research Lab., Research Triangle Park, NC.
NTIS Title Notes Journal article.
Title Annotations Reprint: Effect of 1,3-Dinitrobenzene on Prepubertal, Pubertal, and Adult Mouse Spermatogenesis.
Category Codes 57Y; 57S; 57F
NTIS Prices PC A03/MF A01
Primary Description 600/10
Document Type NT
Cataloging Source NTIS/MT
Control Number 019410415
Origin NTIS
Type CAT