| Main Title |
Cerebellar Hypoplasia in the Gunn Rat is Associated with Quantitative Changes in Neurotypic and Gliotypic Proteins. |
| Author |
O'Callaghan , J. P. ;
Miller, D. B. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc., Research Triangle Park, NC. |
| Year Published |
1985 |
| Report Number |
EPA/600/J-85/410; |
| Stock Number |
PB86-214871 |
| Additional Subjects |
Proteins ;
Bioassay ;
Rats ;
Laboratory animals ;
Morphology ;
Behavior ;
Reprints ;
Neurotoxicity ;
Cerebellar hypoplasia
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB86-214871 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
14p |
| Abstract |
The authors are characterizing toxicant-induced injury to the nervous system by measuring nervous system cell-type specific proteins together with accompanying changes in morphology and behavior. In the present study, cerebellar neurotoxicity was assessed in the Gunn rat an autosomal recessive mutant that exhibits degeneration of Purkinje cells due to hereditary hyperbilirubinemia. Five proteins associated with neuronal or glial cell types were chosen for evaluation as follows: (1) G-substrate, a Purkinje cell-specific phosphoprotein that serves as the endogenous substrate of cyclic GMP-dependent protein kinase; (2) PCPP-260, a Purkinje cell-specific phosphoprotein that serves as an endogenous substrate of cyclic AMP-dependent protein kinase; (3) synapsin I, a synapse-specific phosphoprotein present in all neurons; (4) glial fibrillary acidic protein, an astrocyte-specific protein; and (5) myelin basic protein, a protein unique to myelin. |
| Supplementary Notes |
Pub. in Jnl. of Pharmacology and Experimental Therapeutics, v234 n2 p522-533 Aug 85. Prepared in cooperation with Northrop Services, Inc., Research Triangle Park, NC. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Cerebellar Hypoplasia in the Gunn Rat is Associated with Quantitative Changes in Neurotypic and Gliotypic Proteins. |
| PUB Date Free Form |
c1985 |
| Category Codes |
6O; 57Q |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
624112949 |
| Origin |
NTIS |
| Type |
CAT |
