| Main Title |
Effects of Cell Source, Mouse Strain, and Immunosuppressive Treatment on Production of Virulent and Attenuated Murine Cytomegalovirus. |
| Author |
Selgrade, Maryjane K. ;
Nedrud, John G. ;
Collier, Albert M. ;
Gardner, Donald E. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
| Year Published |
1981 |
| Report Number |
EPA-600/J-81-107; |
| Stock Number |
PB83-189662 |
| Additional Subjects |
Viruses ;
Mice ;
Cells(Biology) ;
Production ;
Reprints ;
Immunosuppression ;
Murine cytomegalovirus
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB83-189662 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
10p |
| Abstract |
Murine cytomegalovirus pools from various in vitro and in vivo sources were compared for virulence in suckling mice in an effort to identify the conditions which were necessary for the production of virulent and attenuated viruses. Virus passaged in tracheal ring and salivary gland organ cultures, where virus is produced primarily by epithelial cells, was even more attenuated than virus passaged in mouse embryo fibroblasts. The attenuation observed after passage in all three of these in vitro systems did not appear to be due to defective interfering particles. |
| Supplementary Notes |
Pub. in Infection and Immunity, v33 n3 p840-847 Sep 81. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Effects of Cell Source, Mouse Strain, and Immunosuppressive Treatment on Production of Virulent and Attenuated Murine Cytomegalovirus. |
| PUB Date Free Form |
1981 |
| Category Codes |
6E; 6M; 57J; 57K |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
320323481 |
| Origin |
NTIS |
| Type |
CAT |
