| Main Title |
Initial Submission: Letter from Rohm and Haas Company to USEPA Toxicity Studies of Triphenylphosphine with Attachments and Letter dated 09/22/1992. |
| CORP Author |
Bio/Dynamics, Inc., Tokyo(Japan).; Rohm and Haas Co., Spring House, PA.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1992 |
| Report Number |
8EHQ-0892-9732 |
| Stock Number |
OTS0570648 |
| Additional Subjects |
Toxicology ;
Health effects ;
Toxic substances ;
Triphenylphosphine ;
Neurotoxicity ;
Mammals ;
Dogs ;
Oral ;
Gavage ;
Acute toxicity ;
Rats ;
Inhalation ;
Primary dermal irritation ;
Rabbits ;
Dermal ;
Primary eye irritation ;
Birds ;
Subchronic toxicity ;
Diet ;
CAS No 603-35-0 ;
CAS No 791-28-6
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0570648 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
9p |
| Abstract |
A total of 12 Beagle dogs were randomly distributed into two groups of 3 animals/sex/group. The test material, triphenylphosphine (TPP), was admini- stered to Group II animals by gastric.intubation at a dose level of 25 mg/kg/day for 21 consecutive days. The Group I (vehicle control) animals received the equivalent awount of corn oil alone. Following the 3 week dosing period, all animals were observed for an additional 4 weeks prior to sacrifice. The administration of TPP did not significantly affect body weight or food consumption. However, 3 out of the 6 animals in Group II exhibited signs of neurological impairment. The signs were first evident approximately 14 days following initiation of TPP treatment and were characterized principally by ataxia and hindlimb weakness. There was a slight improvement noted in the affected animals following cessation of compound administration. Thereafter, no further improvement was noted. No such effects were observed in the vehicle control group. Complete gross postmortem examinations were performed on all animals after 7 weeks. No compound-related effects were observed. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
22 Sep 1992 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A02/MF A02 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
010502760 |
| Origin |
NTIS |
| Type |
CAT |
