| Main Title |
Initial Submission: Toxicity Studies of Triphenyl Phosphite with Cover Letter dated 09/01/1992. |
| CORP Author |
Eastman Kodak Co., Rochester, NY.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1992 |
| Report Number |
8EHQ-0992-10567 |
| Stock Number |
OTS0570901 |
| Additional Subjects |
Toxicology ;
Health effects ;
Toxic substances ;
Triphenyl phosphite ;
Acute toxicity ;
Mammals ;
Rats ;
Oral ;
Gavage ;
Mice ;
Cats ;
Primary dermal irritation ;
Guinea pigs ;
Primary dermal sensitization ;
Primary eye irritation ;
Rabbits ;
CAS No 101-20-0
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0570901 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
6p |
| Abstract |
The report pertains to phosphorous acid, triphenyl ester (synonym: triphenyl phosphite) (CAS No. 101-02-0) and is being submitted because of lethality with central nervous system signs observed in an acute intraperitoneal study in cats, decreased cholinesterase activity observed in an acute intraperitoneal toxicity study in mice, and effects observed in a dermal sensitization study in guinea pigs. The intraperitoneal LD, was less than 100 mg/kg in cats. Intraperitoneal injection of 100 mg/kg and 1,000 mg/kg in mice decreased cholinesterase levels by 20 and 43%, respectively. Abnormalities observed during a dermal sensitization study in guinea pigs included bruising of the skin from touching or handling, suggesting cataneous capillary fragility. The report is being identified as a study involving other than human effects (Unit II.B.2.b of CAP Agreement). |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
4 Sep 1992 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A02/MF A02 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
018800300 |
| Origin |
NTIS |
| Type |
CAT |
