| Main Title |
Initial Submission: Range Finding Toxicity and 7-Day Dietary Inclusion Studies of Ethylenediamine with Cover Letter dated 09/08/1992. |
| CORP Author |
Carnegie-Mellon Univ., Pittsburgh, PA.; Union Carbide Corp., Danbury, CT.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1992 |
| Report Number |
8EHQ-0992-11022 |
| Stock Number |
OTS0571059 |
| Additional Subjects |
Toxicology ;
Health effects ;
Toxic substances ;
Ethylenediamine ;
Acute toxicity ;
Mammals ;
Rats ;
Oral ;
Gavage ;
Rabbits ;
Dermal ;
Primary dermal irritation ;
Primary eye irritation ;
Subchronic toxicity ;
Diet ;
CAS No 107-15-3
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0571059 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
15p |
| Abstract |
Inclusion for seven days of ethylenediamine in the diet of rats resulted in statistically significant dosage-related reductions of body weight in both sexes, and decreases in liver weight per as and in liver weight/body weight ratios. Kidney weight/body weight ratios were significantly increased. Tubular nephrosis was found in both sexes at the two highest dosage levels. No significant effects in either sex were observed at 0.20 gm/kg/day. The ratio of single peroral LD50/MiE vas 2.24, indicating a moderate degree of chronicity. The median predicted minimum effect dosage level for 90-day rat feeding is 0.167 ge/kg; that for two years is 0.093 p/kg (Weil et al., Tox. Appl. Pharmacol 14, 426-431, 1969). |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
8 Sep 1992 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A03/MF A03 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
018800760 |
| Origin |
NTIS |
| Type |
CAT |
