| Main Title |
Initial Submission: Primary Skin Irritation and Sensitization Tests on Guinea Pigs with (1,1'-Biphenyl)2,5-Diol with Cover Letter dated 10/16/1992. |
| CORP Author |
Du Pont de Nemours (E.I.) and Co., Newark, DE. Haskell Lab. for Toxicology and Industrial Medicine.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1992 |
| Report Number |
8EHQ-1092-11746 |
| Stock Number |
OTS0571674 |
| Additional Subjects |
Toxicology ;
Health effects ;
(1 ;
1'-biphenyl)-2 ;
5-diol ;
Primary dermal irritation ;
Mammals ;
Guinea pigs ;
Dermal ;
Primary dermal sensitization ;
CAS No 1079-21-6
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0571674 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
14p |
| Abstract |
The test for primary irritation was conducted by applying, and lightly rubbing in, 1 drop (=0.05 al) each of a 25% and 2.5% solution (wt/vol) of the test material in FAD on the shaved intact shoulder skin of 10 male albino guinea pigs. To test for the sensitization potential, a .series of four sacral intradermal injections was given, one each week over a three-week period, which consisted of 0.1 ml of a 1% solution (wt/vol) of test material in dimethyl phthalate. Following a two-week rest period, the test animals were challenged for sensitization by applying, and lightly rubbing in, 1 drop (=0.05 al) each of a 25% and 2.5% solution (wt/vol) of test material in FAD on the shaved intact shoulder skin. A group of 10 previously unexposed guinea pigs received similar applications at the time of challenge to provide a direct comparison of the challenge reactions on skin of chilar age. After an additional two-week rest period, the animals were rechallenged following the same procedure for the challenge as a further check for sensitization. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
27 Oct 1992 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A03/MF A03 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028700910 |
| Origin |
NTIS |
| Type |
CAT |
