| Main Title |
Future directions in research on genetic toxicology of complex mixtures. / |
| Author |
Lewtas, J.
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. Genetic Toxicology Div. |
| Publisher |
US Environmental Protection Agency, Health Effects Research Laboratory, |
| Year Published |
1990 |
| Report Number |
EPA/600/D-90/246 |
| Stock Number |
PB91-162602 |
| Additional Subjects |
Toxicology ;
Environmental pollutants ;
Mutagens ;
Health hazards ;
Predictive value of tests ;
Carcinogenicity tests ;
Bioassay ;
Risk assessment ;
Mutagenicity tests ;
DNA damage ;
Reprints
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB91-162602 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
11 pages ; 28 cm |
| Abstract |
The future assessment of complex mixtures of environmental pollutants will increasingly rely on new interdisciplinary strategies including state-of-the-art genetic and molecular methodologies. Integrated multidisciplinary studies will assess human exposure, dosimetry and cancer risk to complex mixtures of pollutants and apportion the exposure and risk to the various pollution sources. Strategies which hold promise for future studies include: (1) biomonitoring environmental levels, fate, transformation and human exposure; (2) characterization of the genotoxic components of complex mixtures using advanced chemical and bioassay methods; (3) source apportionment of human exposure to mutagens; (4) molecular dosimetry of complex mixtures, and (5) mechanistic studies of the effects of complex mixtures induced by both genetic and non-genetic mechanisms. Important advances in understanding the genetic and carcinogenic effects of complex environmental mixtures will increasingly rely on the successful implementation of multidisciplinary integration of environmental, laboratory and human studies using state-of-the-art biological, chemical and molecular methods. |
| Notes |
"EPA 600/D-90/246." Microfiche. |
| Place Published |
Research Triangle Park, NC., |
| Supplementary Notes |
Pub. in Genetic Toxicology of Complex Mixtures, v39 p353-361 1990. |
| PUB Date Free Form |
c1990. |
| NTIS Prices |
PC A03/MF A01 |
| BIB Level |
m |
| Cataloging Source |
OCLC/T |
| OCLC Time Stamp |
20010105124529 |
| Language |
eng |
| Origin |
NTIS |
| Type |
MERGE |
| OCLC Rec Leader |
00752nam 2200193Ka 45020 |
