Main Title |
Initial Submission: Subchronic Toxicity of Santowhite Powder in Rats with Cover Letter dated 08/07/1992. |
CORP Author |
Monsanto Chemical Co., St. Louis, MO.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
Year Published |
1992 |
Report Number |
8EHQ-0892-10195 |
Stock Number |
OTS0570777 |
Additional Subjects |
Toxicology ;
Health effects ;
Toxic substances ;
Santowhite powder ;
Subchronic toxicity ;
Mammals ;
Rats ;
Oral ;
Diet ;
CAS No 85-60-9
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
OTS0570777 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
101p |
Abstract |
SANTOWHITE Powder was fed at dietary levels of 0, 1,000, 2,500, 5,000 and 10,000 ppm (parts per million) for approximately four weeks to groups of ten rats of each sex. The neat test material and test diets were stable. The diets were homogeneously prepared and near their target con- centrations. There were no significant clinical signs and all animals survived to the terminal sacrifice. Reduced food intake and lower body weights were noted for both sexes at the three highest dietary levels throughout the study. The liver appeared to be the target organ in this study. Upon gross examination, livers were abnormally colored and there were increased absolute and relative hepatic weights for both sexes at all dietary levels. Microscopically, all dietary levels showed hepa- tocellular vacuolation (lipid accumulation). In addition, the three highest dietary levels also showed hepatocellular hypodegeneration/necrosis. A no-observed-effect-level (NOEL) was not achieved for this study but was considered to be lower than 1,000 ppm in the diet of rats for four weeks. |
Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
PUB Date Free Form |
28 Aug 1992 |
Category Codes |
57Y; 57U; 68G; 99; 44G |
NTIS Prices |
PC A07/MF A07 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
010503010 |
Origin |
NTIS |
Type |
CAT |