| Main Title |
CASE: The Computer-Automated Structure Evaluation Method, Correctly Predicts the Low Mutagenicity for Salmonella of Nitrated Cyclopenta-Fused Polycyclic Aromatic Hydrocarbons. |
| Author |
Rosenkranz, H. ;
Klopman, G. ;
|
| CORP Author |
Case Western Reserve Univ., Cleveland, OH.;Health Effects Research Lab., Cincinnati, OH. |
| Publisher |
c1988 |
| Year Published |
1988 |
| Report Number |
EPA-R-812264; EPA/600/J-88/405; |
| Stock Number |
PB90-111568 |
| Additional Subjects |
Mutagens ;
Toxicity ;
Tables(Data) ;
Salmonella typhimurium ;
Reprints ;
Computer automated structure evaluation(CASE) ;
Polynuclear aromatic hydrocarbons ;
Structure-activity relationship ;
Predictive value of tests
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB90-111568 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
9p |
| Abstract |
Recently the synthesis and purification of a series of nitro-substituted cyclopenta-fused polycyclic aromatic hydrocarbons was reported. On the basis of expected charge distributions, these chemicals were predicted to be potent mutagens, but were found to be only weakly mutagenic for Salmonella. The report suggested that application of CASE, an artificial intelligence system recently developed in these laboratories, would also not predict the low mutagenicity of this group of chemicals. In the present report, it is shown that CASE, in fact, correctly predicts the low mutagenicity of nitro-substituted cyclopenta-fused polycyclic aromatic hydrocarbons.(Copyright (c) 1988 Elsevier Science Publishers B.V. Biomedical Division.) |
| Supplementary Notes |
Pub. in Mutation Research, v199 p95-101 1988. Sponsored by Health Effects Research Lab., Cincinnati, OH. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: CASE: The Computer-Automated Structure Evaluation Method, Correctly Predicts the Low Mutagenicity for Salmonella of Nitrated Cyclopenta-Fused Polycyclic Aromatic Hydrocarbons. |
| Category Codes |
57Y; 57F |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/10 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
935218791 |
| Origin |
NTIS |
| Type |
CAT |
