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RECORD NUMBER: 493 OF 4624

Main Title Bioassay-Directed Chemical Analysis in Environmental Research.
Author Schuetzle, D. ; Lewtas, J. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Ford Motor Co., Dearborn, MI. Research Staff.
Year Published 1986
Report Number EPA/600/J-86/220;
Stock Number PB87-169553
Additional Subjects Air pollution ; Chemical analysis ; Bioassay ; Contaminants ; Reprints ; Particulates ; Pollutants
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NTIS  PB87-169553 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 11p
Abstract The use of short-term bioassay tests in conjunction with analytical measurements, constitute a powerful tool for identifying important environmental contaminants. The authors have coined the terminology 'bioassay directed chemical analysis' to best describe this marriage of analytical chemistry and biology. The objective of this methodology is to identify key compounds in various types of air pollutant samples. Once that task is completed, studies on metabolism, sources, environmental exposure and atmospheric chemistry can be undertaken. The principles and methodologies for 'bioassay directed chemical analysis' are presented and illustrated in this paper. Most of this work has been directed toward the characterization of ambient air and diesel particulates which we will use as examples in this report to illustrate the analytical logic used for identifying the bio-active components of complex mixtures.
Supplementary Notes Pub. in Analytical Chemistry 1986, v58 n1060A 11p. Prepared in cooperation with Ford Motor Co., Dearborn, MI. Research Staff.
NTIS Title Notes Journal article.
Title Annotations Reprint: Bioassay-Directed Chemical Analysis in Environmental Research.
PUB Date Free Form c1986
Category Codes 99A; 68A
NTIS Prices PC A02/MF A01
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 716917824
Origin NTIS
Type CAT