| Main Title |
Controlled Clinical Evaluations of Chlorine Dioxide, Chlorite and Chlorate in Man. |
| Author |
Lubbers, Judith R. ;
Chauan, Sudha ;
Bianchine, Joseph R. ;
|
| CORP Author |
Ohio State Univ., Columbus. Coll. of Medicine.;Health Effects Research Lab., Research Triangle Park, NC. |
| Year Published |
1982 |
| Report Number |
EPA-R-805643; EPA-600/J-81-367; |
| Stock Number |
PB83-187856 |
| Additional Subjects |
Disinfectants ;
Chlorine dioxide ;
Chlorite ;
Chlorate ;
Toxicology ;
Humans ;
Safety ;
Tolerance(Physiology) ;
Physiological effects ;
Reprints ;
Water pollution effects(Humans)
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB83-187856 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
8p |
| Abstract |
To assess the relative safety of chronically administered chlorine water disinfectants in man, a controlled study was undertaken. The clinical evaluation was conducted in the three phases common to investigational drug studies. Phase I, a rising does tolerance investigation, examined the acute effects of progressively increasing single doses of chlorine disinfectants to normal healthy adult male volunteers. Phase II considered the impact on normal subjects of daily ingestion of the disinfectants at a concentration of 5mg/l. for twelve consecutive weeks. Persons with a low level of glucose-6-phosphate dehydrogenase may be expected to be especially susceptible to oxidative stress; therefore, in Phase III, chlorite at a concentration of 5mg/l. was administered daily for twelve consecutive weeks to a small group of potentially at-risk glucose-6-phosphate dehydrogenase-deficient subjects. |
| Supplementary Notes |
Pub. in Environmental Health Perspectives, v46 p57-62 1982. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Controlled Clinical Evaluations of Chlorine Dioxide, Chlorite and Chlorate in Man. |
| PUB Date Free Form |
1982 |
| Category Codes |
6T; 6F; 57Y; 68D |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
320321834 |
| Origin |
NTIS |
| Type |
CAT |
