||Initial Submission: Subchronic Feeding Toxicity Studies of Phthalic Acid, Di-N-Octyl, N-Decyl Ester with Cover Letter dated 07/20/1993.
||Vista Chemical Co., Houston, TX.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Health effects ;
Phthalic acid ;
N-decyl ester ;
Subchronic toxicity ;
CAS No 119-07-3
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||In the range finding study, groups of 5 male and 5 female F344 rats were fed DODP in the diet at levels of 0(control),0.1, 0.3 and 1.0% for 14 days. The rats were weighed before treatment, on the first day of treatment and thereafter twice weekly until necropsy. After an overnight fast, the animals were sacrificed and the weights of liver, kidneys and testes recorded. The livers from each animal were biochemically analysed for cyanide-insensitive palmitoyl-CoA oxidation and protein concentration. The results from this study were such that they indicated that the dose levels selected should be repeated in the 90-day feeding and 28-day peroxisome proliferation study.
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|PUB Date Free Form
||20 Jul 1993
||57Y; 57U; 68G; 99; 44G
||PC A15/MF A15