| Main Title |
Dibutyl Phthalate: Maternal Effects versus Fetotoxicity (Journal Version). |
| Author |
Cummings, A. M. ;
Gray, L. E. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
| Publisher |
1987 |
| Year Published |
1987 |
| Report Number |
EPA/600/J-87/409; |
| Stock Number |
PB89-105555 |
| Additional Subjects |
Ovum implantation ;
Phthalates ;
Toxic substances ;
Toxicity ;
Decidua ;
Pregnancy ;
Laboratory animals ;
Uterus ;
Organ weight ;
Teratogens ;
Ovary ;
Females ;
Progesterone ;
Reprints ;
Dibutyl phthalate ;
Phthalic acid/dibutyl ester
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB89-105555 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
10p |
| Abstract |
Dibutyl phthalate, a plasticizer, is a teratogen in mice and rabbits but produces fetal loss in the rat. Long-term dosing studies indicating reduced fertility in the rat suggested a maternal effect of the compound. The decidual cell response (DCR) and pregnant rats were used to examine whether DBP affects maternal physiological parameters independent of the compound's fetotoxic effect. DBP has no effect on the DCR, pregnant uterine weight, number of implantation sites, ovarian weight, or serum progesterone concentration during early pregnancy or pseudopregnancy. These data show that short term dosing with DBP has no direct maternal effect in the rat and suggest that the viability of preimplantation embryos is not compromised. |
| Supplementary Notes |
Pub. in Toxicology Letters, v39 p43-50 1987. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Dibutyl Phthalate: Maternal Effects versus Fetotoxicity (Journal Version), |
| Category Codes |
57Y; 57U; 44G; 68G |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
834421735 |
| Origin |
NTIS |
| Type |
CAT |
