| Main Title |
Adsorption, Distribution, Metabolism and Excretion of Cyclohexane (June 1984). |
| CORP Author |
Research Triangle Inst., Research Triangle Park, NC.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
2000 |
| Report Number |
40-8423127 |
| Stock Number |
OTS0527475 |
| Additional Subjects |
Toxicology ;
Health effects ;
Cyclohexane ;
Pharmaco Kinetics ;
Mammals ;
Rats ;
Parenteral ;
Intravenous ;
Oral ;
Gavage ;
Toxic substances ;
Laboratory animals ;
CAS No 110-82-7
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0527475 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
70p |
| Abstract |
The pharmacokinetics of cyclohexane was studied in adult male Fischer 344 rats administered 10 mg/kg 14C-cyclohexane by intravenous injection. At 72 hours, the concentration of 14C in adipose averaged 16 times that in blood. Cyclohexane accounted for 79 to 84% of the radiolabel in adipose, but only 1 to 18% of it in muscle, liver and skin. Small amounts of cyclohexanone and cyclohexanol accounted for the remainder of the C14 present. Most of the radiolabel was excreted in the breath (54% in the 1st hour; 80% in 24 hours, and 83% in 72 hours), 14% in urine, and trace amounts in feces. After oral administration of 2000, 1000, 200, or 100 mg/kg of 14C-cyclohexanone to rats , 78, 76, 62, and 63% C14, respectively, was eliminated in the breath, and 12, 15, 29, and 29% in urine. Again, trace amounts of C14 were eliminated in feces. Three major urinary metabolites, apparently conjugated forms that constituted approximately 1 to 15% of the radioactive dose, were observed but not characterized. Plasma content of 14C was fairly constant (approximately 9.0 to 14.1 ug-eq/g of plasma) from 2 to 12 hours post treatment, but decreased to about 20% of this by 24 hours. Cyclohexane, cyclohexanone, and cyclohexanol accounted for most of the plasma 14C at 6 to 24 hourspost-dosing. At least 5 other unidentified metabolites were found (at 14C-concentrations ranging from approximately 0.14 to 0.74 ug-eq/g at 24 hours). Distribution followed the same pattern after oral dosing as after intravenous administration. The half-lives of total 14C in plasma and tissues, including adipose, were generally about 10 to 15 hours. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
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| PUB Date Free Form |
2000 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A05/MF A05 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028802830 |
| Origin |
NTIS |
| Type |
CAT |
