| Main Title |
Propylene Dichloride: Pharmacokinetics & Metabolism in Fischer 344 Rats Following Oral and Inhalation Exposure. |
| CORP Author |
Dow Chemical Co., Midland, MI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1989 |
| Report Number |
40-8967188 |
| Stock Number |
OTS0527713 |
| Additional Subjects |
Toxicology ;
Health effects ;
1 ;
2-dichloropropane ;
Pharmaco Kinetics ;
Mammals ;
Rats ;
Oral ;
Gavage ;
Inhalation ;
Toxic substances ;
Laboratory animals ;
CAS No 78-87-5
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0527713 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
120p |
| Abstract |
The pharmacokinetics of 1,2-dichloropropane (DCP) was evaluated in Fischer 344 rats following oral and inhalation exposure. Three groups of 4 rats/sex were administered either single doses of 1 or 100 mg/kg 14C-DCP by gavage, or 7 daily oral doses of 1 mg/kg/day non-radiolabled DCP followed by a single oral dose of 1 mg/kg 14C- DCP on day 8. Tissue, urine, and fecal analyses were conducted at 48 hours post-dosing. No signs of toxicity were observed at any dose. Radioactivity was distributed to all tissues, with the liver containing the highest 14C activity (0.229 to 0.41% of dose/g wet weight). The principle routes of elimination of radioactivity were in urine (37 to 52% of dose) and expired air (23 to 36%), with most occurring during the 1st 24 hours after dosing. Feces contained 5.5 to 7.9%, and tissues and carcass accounted for 7.1 to 10.6%. No parent DCP was noted in urine, but about 82% of radioactivity in expired air was parent compound. Three mercapturic acid metabolites of DCP were identified. No differences were noted between sexes or dose levels. Groups of 4 rats/sex/dose were exposed by inhalation (head only) to 5, 50, or 100 ppm 14C-DCP, 6 hours/day for 2 weeks. No signs of toxicity were observed. The overall disposition was similar tothat following oral administration, and dose-related saturation of metabolic sites was evident following both routes of administration. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
1989 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A07/MF A07 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028802870 |
| Origin |
NTIS |
| Type |
CAT |
