Main Title |
Metabolism of 2-chloro'u-ring-14c/toluene by Rats Dosed Intravenously. |
CORP Author |
Occidental Chemical Corp., Grand Island, NY.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
Year Published |
2000 |
Report Number |
40-8335096 |
Stock Number |
OTS0507459 |
Additional Subjects |
Toxicology ;
Health effects ;
2-chlorotoluene ;
Pharmaco Kinetics ;
Mammals ;
Rats ;
Parenteral ;
Intravenous ;
Toxic substances ;
Laboratory animals ;
CAS No 95-49-8
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Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
OTS0507459 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
15p |
Abstract |
The metabolism of 2-chlorotoluene was examined in 4 female rats (strain not reported) injected intravenously with a single 0.7 mg/kg dose of (U-ring-14C)2-chlorotoluene. Rats eliminated 69-81% and 14-18% of the applied dose in the urine and as expired volatiles, respectively, within 4 days after dosing. Nearly all of the volatile 14C in expired air was 2-chlorotoluene. The primary urinary metabolites were mercapturic acid, glucuronide, and 2- chlorohippurate, representing 22-24, 13-20, and 7-11% of urinary 14C, respectively. |
Supplementary Notes |
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Availability Notes |
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PUB Date Free Form |
2000 |
Category Codes |
57Y; 57U; 68G; 99; 44G |
NTIS Prices |
PC A03/MF A03 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
028801220 |
Origin |
NTIS |
Type |
CAT |