||Initial Submission: Summary of Toxicokinetic Studies on Bis(Tributyltin) Oxide (TBTO) Performed at Schering with Cover Letter dated 09/29/1992.
||Schering AG.; Elf Atochem North America, Philadelphia, PA.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Health effects ;
Tributyltin oxide ;
Acute toxicity ;
Pharmaco kinetics ;
Tissue concentration ;
CAS No 56-35-9
||Some EPA libraries have a fiche copy filed under the call number shown.
||Four groups of each 5 male rats received a daily dose of 5 mg TBTO/kg as aqueous suspension once, three times, 7 times, and 14 times, respectively. Organ and tissue specimens were removed in each case 24 hours after the single (last) dose. Urine and feces were collected in daily frac- tions in that group of animals treated for 14 days. As was shown by a preexperiment in bile duct cannulated animals only about 20 % of TBTO dose administered was absorbed in this study. Excluding the radioactivity located in the gastro-intestinal tract (GIT), on an average 12 + or - 2 % of the administered dose was detectable in the animal bodies 24 hours after i.g. administration.
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|PUB Date Free Form
||13 Oct 1992
||57Y; 57U; 68G; 99; 44G
||PC A04/MF A04