| Main Title |
Up and down Procedure for Estimating Acute Oral Toxicity (ld50) in Rats with Cover Letter dated 08/21/1986. |
| CORP Author |
Hazleton Labs. America, Inc., Madison, WI.; Proctor and Gamble Co., Cincinnati, OH. Ivorydale Technical Center.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1986 |
| Report Number |
86860000122 |
| Stock Number |
OTS0510267 |
| Additional Subjects |
Toxicology ;
Health effects ;
P-(tert-butyl)benzoic Acid (98-73-7) ;
Acute Toxicity ;
Mammals ;
Rats ;
Oral ;
Gavage ;
Toxic substances ;
Laboratory animals ;
CAS No 98-73-7
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0510267 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
86p |
| Abstract |
Acute oral toxicity was evaluated in Sprague-Dawley rats administered p-tert-butyl benzoic acid using an up and down schedule. Mortality was observed in 1 out of 3 males receiving doses of 0.7 g/kg body weight, in 2 out of 2 males receiving doses of 0.9 g/kg, and in all 6 females receiving doses of 0.7 g/kg body weight. The LD50 value was determined to be 0.72 g/kg (95% confidence limits of 0.54 to 0.98 g/kg) in males; and was estimated to be less than 0.70 g/kg in females. Clinical observations included hypoactivity, ataxia, thin appearance, hunched posture, impaired use of front limbs, yellow-stained anal area, tremors, prostration, excess salivation, hypothermia, bradypnea, absence of pain reflex, spasticity, mydriasis, flaccidity, and respiratory congestion. One animal also exhibited cyanosis, absence of pain reflex, and a reddish material on its face and front paws. Gross necropsy of decedents and animals sacrificed at 7 days revealed: diffusely red glandular mucosa in stomachs; clear fluid in stomachs; enlarged stomach with clear red mucoid fluid; tan to dark tan mucoid material in intestines; red perinasal discharge; and enlarged right submandular lymph nodes. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with Proctor and Gamble Co., Cincinnati, OH. Ivorydale Technical Center. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
1986 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A06/MF A06 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028801410 |
| Origin |
NTIS |
| Type |
CAT |
