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OLS Field Name OLS Field Data
Main Title Developmental Toxicity of Dinocap in the Mouse is not Due to Two Isomers of the Major Active Ingredients (Journal Version).
Author Rogers, J. M. ; Gray, L. E. ; Carver, B. D. ; Kavlock, R. J. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Publisher 1987
Year Published 1987
Report Number EPA/600/J-87/415;
Stock Number PB89-105852
Additional Subjects Toxic substances ; Fungicides ; Teratogens ; Fetus ; Isomers ; Laboratory animals ; Nitrogen organic compounds ; Prenatal exposure delayed effects ; Pregnancy ; Cleft palate ; Fetal viability ; Body weight ; Otoliths ; Reprints ; Dinocap ; Butenoic acid/methyheptyl-dinitrophenyl ester
Library Call Number Additional Info Location Last
NTIS  PB89-105852 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 03/14/1989
Collation 8p
Abstract The developmental toxicities of 2,4-dinitro-6-(1-methylheptyl)phenyl crotonate and 2,6-dinitro-4-(1-methylheptyl)phenyl crotonate, model isomers of the major active ingredients of technical dinocap, were compared to the known teratogenicity of the technical compound. Individual isomers, both isomers combined, or technical dinocap were administered to pregnant mice on days 7-16 of gestation. Similar to previous studies, technical grade dinocap caused cleft palate and weight deficits in fetuses at term and increased neonatal mortality and abnormal swimming behavior, torticollis, and deficient otolith formation in surviving pups. Neither of the purified isomers exhibited any developmental toxicity when administered under identical conditions. Thus, it is concluded that these isomers are not the active teratogenic component(s) in technical grade dinocap.
Supplementary Notes Pub. in Teratogenesis, Carcinogenesis, and Mutagenesis, v7 p341-346 1987.
NTIS Title Notes Journal article.
Title Annotations Reprint: Developmental Toxicity of Dinocap in the Mouse Is Not Due to Two Isomers of the Major Active Ingredients (Journal Version).
Category Codes 57Y; 57U; 44G; 68E; 68G
NTIS Prices PC A02/MF A01
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 833027548
Origin NTIS
Type CAT